Eagle Butte is the largest city on the Cheyenne River Reservation, a sovereign Lakota Nation in the state of South Dakota. The city is home to tribal headquarters. Like the rest of the U.S., Cheyenne River has reached a Covid-19 vaccination plateau. But in Cheyenne River, the root cause of hesitancy is lingering mistrust of the U.S. government tied to the history of betrayal. March 11, 2021.